Dopaminergic modulation of low- and high spontaneous rate-type I auditory nerve fiber activity
dopamine receptor genes was investigated in the cochlea. Dopamine and a D1-like receptor agonist reduced SR of both low- and high-SR ANFs, and this effect was blocked by a D1-like receptor antagonist. A D2-like agonist did not show similar inhibition, but the data cannot fully exclude a possible effect of D2-like receptors. Reporter mouse models suggest expression of the gene for the D1 receptor in both ANFs and efferent LOC neurons, whereas the gene for the D2 receptor was found only in efferent LOC neurons in the apex of the cochlea. These data provide evidence that dopamine inhibits all ANF subtypes through D1-like receptors.
Authors
- Kevin J. Psoter (ORCID: https://orcid.org/0000-0001-8529-0585)
- Eunyoung Yi (ORCID: https://orcid.org/0000-0002-9592-0736)
- Philippe Vincent (ORCID: https://orcid.org/0000-0001-7712-7198)
- Kushal Sharma (ORCID: https://orcid.org/0000-0001-6554-0479)
- Daniël O. J. Reijntjes (ORCID: https://orcid.org/0000-0002-6485-588X)
- Sherry Jingjing Wu (ORCID: https://orcid.org/0000-0001-9625-1661)
- Elisabeth Glowatzki (ORCID: https://orcid.org/0000-0003-3135-658X)
- Marco Manca (ORCID: https://orcid.org/0000-0001-9569-2924)
- Grace Tate
Institutions
- Mokpo National University (KR)
- Harvard University (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Sova Pharmaceuticals (United States) (US)
Publication Details
- Journal
- Journal of Neurophysiology
- Published
- 2026-04-21
- DOI
- https://doi.org/10.1152/jn.00484.2025
- Primary Topic
- Hearing, Cochlea, Tinnitus, Genetics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation of Korea
- National Institute on Deafness and Other Communication Disorders