Rejuvenating hematopoietic stem cells to extend health and lifespan

Rejuvenating hematopoietic stem cells to extend health and lifespan Maria Carolina Florian explores the complexities of aging and research on the hematopoietic system, particularly focusing on hematopoietic stem cells (HSCs), as well as how rejuvenating strategies targeting the hematopoietic system could enhance healthspan and lifespan. Aging is a complex and fascinating biological process, which broadly reflects the decline of organismal and cellular function over time. While the community is building a consensus over the hallmarks of aging(1), the identification of druggable targets that would not only correct the specific dysregulated hallmark, but also more holistically improve healthspan and lifespan of the organism is still highly controversial.