Self‐Evolving Hydrogel Dressing Temporally Accelerates Infected Diabetic Wound Healing

to combat multidrug-resistant biofilm-forming bacteria. Subsequently, Ag nanozymes with superoxide dismutase/catalase-like activities continuously scavenge reactive oxygen species while generating oxygen, facilitating macrophage M1-to-M2 repolarization and ensuing inflammatory-to-proliferative phase transition. Accumulated ammonia enhances cell proliferation, migration and angiogenesis. The dressing demonstrates exceptional biocompatibility and bioactivity in accelerating Staphylococcus aureus-infected full-thickness cutaneous wound healing in a diabetic rat model, as validated by hemostatic, broad-spectrum antibacterial, antioxidative and immunomodulatory abilities, enhanced oxygenation and cell proliferation, and extensive collagen deposition, vascularization and re-epithelialization. RNA-seq results further reveal the activation of multiple pro-healing signaling axes. Consequently, this platform offers a powerful dynamic strategy of realizing robust antibacterial activity and active temporal niche modulation to guide the healing of infected diabetic wounds.