Outstanding Questions to Understand and Target Splicing Factor–Mutant Blood Cancers
Mutations in genes encoding RNA splicing factors are common in patients with myeloid malignancies and chronic lymphocytic leukemia. In this commentary, we discuss key unanswered questions on the causal role of these mutations in blood cancers and precursor conditions as well as efforts to develop therapies targeting these high-frequency neomorphic mutations.
Authors
- Maxim I. Maron (ORCID: https://orcid.org/0000-0001-7809-5888)
- Omar Abdel‐Wahab (ORCID: https://orcid.org/0000-0002-3907-6171)
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- Kettering University (US)
Publication Details
- Journal
- Blood Cancer Discovery
- Published
- 2026-04-21
- DOI
- https://doi.org/10.1158/2643-3230.bcd-26-0047
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Damon Runyon Cancer Research Foundation
- Edward P. Evans Foundation
- Break Through Cancer
- National Institutes of Health