Illuminating cancer therapy: The translational path of optogenetics
. Furthermore, we summarize emerging preclinical applications in cancer immunotherapy, gene regulation, and intracellular signaling control. Finally, we discuss key challenges in biosafety, kinetic optimization, and clinical scalability, and outline future directions that integrate optogenetics with functional materials and intelligent design to realize clinically viable platforms. This review aims to provide a framework for the development of clinically viable optogenetic platforms for next-generation cancer therapy.
Authors
- Zhichang Liu (ORCID: https://orcid.org/0000-0003-3412-512X)
- 郑秀丽
- Qiyi Feng (ORCID: https://orcid.org/0000-0003-1437-644X)
- Jingyao Chen (ORCID: https://orcid.org/0000-0002-4934-7983)
- Bing Yang
- Kai Xiao (ORCID: https://orcid.org/0000-0002-6767-8866)
- Chunxiu Xiao
- Shuwen Xiao
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Bioactive Materials
- Published
- 2026-04-21
- DOI
- https://doi.org/10.1016/j.bioactmat.2026.04.019
- Primary Topic
- Photoreceptor and optogenetics research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National University's Basic Research Foundation of China
- Sichuan Province Science and Technology Support Program
- Chengdu Science and Technology Program