Spatiotemporal Transcriptomics Characterizes Immune Microenvironment During Mouse Liver Aging
T cell exhaustion was tightly associated with disease progression. Therefore, our findings suggest that targeting LPIN1 may alleviate T cell exhaustion, offering potential therapeutic strategies for age-related liver diseases.
Authors
- Zhaoya Gao (ORCID: https://orcid.org/0000-0002-0874-2266)
- Jin Gu (ORCID: https://orcid.org/0000-0002-9650-1963)
- W H Zhao
- Jie Cheng
- Zihao Zhao
- Yuqian Wang
- Cheng Li
Institutions
- Peking University (CN)
- Precision for Medicine (United States) (US)
- Peking University International Hospital (CN)
- Peking University Shougang Hospital (CN)
- Ministry of Education (ET)
- Huazhong University of Science and Technology Hospital (CN)
- Center for Life Sciences (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Aging Cell
- Published
- 2026-04-20
- DOI
- https://doi.org/10.1111/acel.70482
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Science and Technology Major Project
- Beijing Municipal Natural Science Foundation
- National Key Research and Development Program of China