Suppressive effect of lemon (<i>Citrus limon</i> L. Burm. f.) extract toward pro-tumor immune response in DMBA-induced carcinogenesis mouse.

Objective: extract (CLE) in 7,12-Dimethylbenz[a]anthracene (DMBA)-induced carcinogenesis mice. Materials and Methods: . Results: In this study, we discovered that CLE reduces the number of immune system profiles to normal levels, including granulocytes, macrophages, natural killer cells, and effector T cells, while increasing the population of regulator T cells to normal levels. Moreover, the absorption, distribution, metabolism, excretion, and toxicity (ADMET) evaluation showed that several significant CLE compounds meet the drug-like requirements. Conclusion: This research revealed that CLE might be developed as a supplemental or additional cancer treatment.