Red-Light Photoredox C–H Alkylation of Acceptor Heterocycles Enabled by Substoichiometric NADH
)-H alkylation of acceptor heterocycles. This strategy reduces waste and leads to excellent yields and selectivity by suppressing overreduction. The reaction proceeds in air, under mild, aqueous-compatible conditions and operates in biorelevant media, establishing NADH as a cofactor for artificial red-light photoredox catalysis.
Authors
- Mauro Mato (ORCID: https://orcid.org/0000-0002-2931-5060)
- María Tomás‐Gamasa (ORCID: https://orcid.org/0000-0001-8681-2744)
- José L. Mascareñas (ORCID: https://orcid.org/0000-0002-7789-700X)
- Alejandro Cadranel (ORCID: https://orcid.org/0000-0002-6597-4397)
- Uxía Deus-Lorenzo
- Riccardo Di Forti
Institutions
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Universidade de Santiago de Compostela (ES)
- Universidad de Buenos Aires (AR)
- Center for Research in Molecular Medicine and Chronic Diseases (ES)
- Instituto de Química y Fisicoquímica Biológicas (AR)
- Fundación Ciencias Exactas y Naturales (AR)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-04-21
- DOI
- https://doi.org/10.1021/acs.orglett.6c01113
- Primary Topic
- Enzyme Catalysis and Immobilization
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia
- Xunta de Galicia
- Agencia Estatal de Investigación