Prenatal Diagnosis of Posterior Urethral Valves: Timing of Diagnosis and Mid‐Term Renal Function When Second and Third Trimester Ultrasounds Are Systematically Performed
OBJECTIVE: The impact of prenatal diagnosis timing in posterior urethral valves is unclear. We aimed to compare renal function between patients with suspected PUV diagnosed before or after 28 weeks of gestation in a population who underwent systematic T2 and T3 ultrasounds. METHODS: We performed a retrospective analysis of a prospective cohort of patients with prenatally suspected and postnatally confirmed PUV. Patients were stratified by timing of prenatal ultrasound detection of urinary tract abnormalities (T2 vs T3). We compared nadir creatinine and mid-term eGFR (> 5 years of follow-up). RESULTS: , p < 0.05) compared to the T3 group. CONCLUSIONS: PUV suspected during the second trimester of gestation is associated with significantly worse NC and mid-term renal function compared with those suspected later in pregnancy (T3). Reports of prenatal diagnosis of PUV should dichotomize between T2 and T3 diagnoses. The true rate of PUV that could be diagnosed prenatally is higher than expected.
Authors
- Nadia Boudaoud
- Nicolas Kalfa (ORCID: https://orcid.org/0000-0001-5472-4096)
- Alice Faure (ORCID: https://orcid.org/0000-0002-3327-6391)
- Matthieu Peycelon (ORCID: https://orcid.org/0000-0003-3617-4849)
- Etienne Suply (ORCID: https://orcid.org/0000-0003-2224-7752)
- Mathilde Glénisson
- Pauline Clermidi
- Sébastien Faraj (ORCID: https://orcid.org/0000-0002-5875-6121)
- Marc‐David Leclair (ORCID: https://orcid.org/0000-0002-1771-9025)
- Quentin Ballouhey (ORCID: https://orcid.org/0000-0002-6817-9946)
- Silvia Pecorelli
- Alexis Arnaud (ORCID: https://orcid.org/0000-0003-4378-3570)
- Thomas Blanc (ORCID: https://orcid.org/0000-0002-5829-8167)
- Yann Chaussy (ORCID: https://orcid.org/0000-0002-7175-1341)
- Luke Harper
Institutions
- University of Reunion Island (RE)
- Centre Hospitalier Universitaire de Nantes (FR)
- Sorbonne Université (FR)
- Institut Necker Enfants Malades (FR)
- Hôpital Armand-Trousseau (FR)
- Assistance Publique Hôpitaux de Marseille (FR)
- Centre Hospitalier Universitaire de La Réunion (RE)
- Centre Hospitalier Universitaire de Besançon (FR)
- Centre Hospitalier Universitaire de Montpellier (FR)
- Centre Hospitalier Universitaire de Reims (FR)
- Hôpital Pellegrin (FR)
- Centre Hospitalier Universitaire de Limoges (FR)
- Hôpital Robert-Debré (FR)
- Centre d'Investigation Clinique de Nantes (FR)
- Délégation Provence et Corse (FR)
- Centre Hospitalier Universitaire de Rennes (FR)
- Observatoire des Sciences de l'Univers de la Réunion (RE)
- Université de Reims Champagne-Ardenne (FR)
Publication Details
- Journal
- Prenatal Diagnosis
- Published
- 2026-04-21
- DOI
- https://doi.org/10.1002/pd.70155
- Primary Topic
- Pediatric Urology and Nephrology Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00