RNA methylation in urological cancers: regulatory logic, biological functions, and clinical relevance
A detection technologies and discuss their methodological strengths, limitations, and appropriate research applications. Beyond mechanistic insights, we discuss the emerging clinical relevance of RNA methylation regulators in urological malignancies, particularly in relation to diagnostic-related evidence, prognostic stratification, immune-related relevance, and treatment-associated adaptation. In addition, we summarize current therapeutic efforts targeting RNA methylation pathways, including small-molecule inhibitors and related translational strategies, while emphasizing their present limitations. Overall, current evidence supports RNA methylation as a biologically important and increasingly translationally relevant framework in urological cancers, but not yet as a clinically mature one.
Authors
- Huangheng Tao (ORCID: https://orcid.org/0000-0002-5530-0911)
- Jiahao Peng (ORCID: https://orcid.org/0000-0002-4028-383X)
- Chenhao Tang (ORCID: https://orcid.org/0000-0002-4045-7377)
- Mingyang Yi (ORCID: https://orcid.org/0009-0009-0638-2306)
- Ziyang Liu (ORCID: https://orcid.org/0000-0003-1984-7378)
- Zuowei Yuan
- Zhiying Wang (ORCID: https://orcid.org/0000-0002-7226-1686)
- Minhao Liu (ORCID: https://orcid.org/0000-0003-4120-2269)
- Feng Tang
- Xuran Liu
- Longwei Liao
- Li Yu
- Wei Wei
- Chong Xie
- Xinpan Zou
- Zhangmin Xie
- Yixiang Liao
- Tao Liu
Institutions
- Qingdao University (CN)
- Nanchang University (CN)
- Yangtze University (CN)
- Wuhan University (CN)
- Jiangxi Provincial People's Hospital (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- Qingdao Municipal Hospital (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Stomatology Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-04-21
- DOI
- https://doi.org/10.3389/fimmu.2026.1790638
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00