Yoda1-activated Piezo1 enhances mitophagy in human gingival fibroblasts to promote maxillofacial wound repair

Background: Delayed healing of maxillofacial soft tissue wounds is closely associated with inffammatory injury and mitochondrial dysfunction in fibroblasts, while effective therapeutic strategies remain limited. This study investigated whether activation of the mechanosensitive ion channel Piezo1 by Yoda1 could promote wound healing. Methods: inflammatory wound model was used to evaluate therapeutic efficacy. Results: , Yoda1 accelerated wound closure, accompanied by increased collagen deposition and improved tissue regeneration. Conclusion: Activation of Piezo1 by Yoda1 can alleviate its inflammatory damage by restoring mitochondrial homeostasis and regulating the cellular functions of HGFs. Piezo1 may be a promising therapeutic target for promoting maxillofacial wound repair.