Connecting dots: Ligand-dependent allostery from protein interaction to gene regulation
Biomolecular function emerges from dynamic conformational landscapes and allosteric regulation within modular, multicomponent assemblies. Genome-wide analysis of RARα:RXR shows how ligand-dependent allostery reshapes chromatin targeting and gene networks, highlighting opportunities to tune signaling pathways and design next-generation therapeutics.
Authors
- Giorgio Colombo (ORCID: https://orcid.org/0000-0002-1318-668X)
Institutions
- University of Pavia (IT)
Publication Details
- Journal
- Cell Reports
- Published
- 2026-04-21
- DOI
- https://doi.org/10.1016/j.celrep.2026.117327
- Primary Topic
- Signaling Pathways in Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fondazione AIRC per la ricerca sul cancro ETS