Trends in Sepsis-Associated Respiratory Disease Mortality in the United States, 1999 to 2023

= .017), with a rise from 1999-2018 (APC=1.86%), a surge from 2018-2021 (APC=11.47%), and a decline from 2021-2023 (APC=-12.82%). Males, American Indian or Alaska Native populations, middle-aged adults (45-64 years), and Western/Southern states showed the largest increases. Most deaths (88.16%) occurred in medical facilities.ConclusionSepsis-associated respiratory mortality rose over 25 years, with a pronounced COVID-19-driven surge (2018-2021) and partial post-2021 decline. Persistent disparities by sex, race, age, and region highlight the need for targeted interventions, improved screening, and equity-focused policies to address systemic vulnerabilities.