A Novel Genetic Engineering Approach for DON Detoxification Using a Yeast-Based Multi-Enzyme System
< 0.05), as confirmed by HPLC-MS, while the strain expressing only the PQQ cluster showed no detoxification activity. This study establishes an integrated yeast cell factory for DON detoxification and highlights key limitations to guide future optimization efforts.
Authors
- Aike Li
- Jingjing Shi (ORCID: https://orcid.org/0000-0002-7817-6407)
- Weiwei Wang (ORCID: https://orcid.org/0000-0002-5398-6809)
- Bo Sun
- Chen Zhao
- Jia Song
- Qingming Cao (ORCID: https://orcid.org/0000-0003-2783-2424)
- Ming Liu
- Shiqi Zou
- Linshu Jiang (ORCID: https://orcid.org/0000-0002-9076-5749)
Institutions
- Central South University of Forestry and Technology (CN)
- Central South University (CN)
- Academy of National Food and Strategic Reserves Administration (CN)
- Beijing University of Agriculture (CN)
Publication Details
- Journal
- Biology
- Published
- 2026-04-21
- DOI
- https://doi.org/10.3390/biology15080654
- Primary Topic
- Microbial metabolism and enzyme function
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Key Research and Development Program of China