Effects of Infliximab in a Propionic Acid-Induced Experimental Autism Rat Model
: These findings suggest that TNF-α suppression alone does not normalize the disrupted cytokine-neurotrophin axis and may differentially modulate BDNF-related neuroplastic signaling during development. In conclusion, this study indicates that non-selective TNF-α blockade during neurodevelopment fails to confer behavioral benefit in experimental ASD and highlights the importance of considering cytokine-BDNF pathway interactions when designing immunomodulatory strategies for neurodevelopmental disorders.
Authors
- Ahmet Ateşşahín (ORCID: https://orcid.org/0000-0002-1004-2146)
- Osman Yılmaz (ORCID: https://orcid.org/0000-0003-2013-9213)
- Salih ÇİBUK (ORCID: https://orcid.org/0000-0001-5427-4929)
- Ahmet Ufuk Kömüroğlu
- Fikret Altındağ
Institutions
- Van Yüzüncü Yıl Üniversitesi (TR)
- Elazığ Eğitim ve Araştırma Hastanesi (TR)
Publication Details
- Journal
- Biomedicines
- Published
- 2026-04-20
- DOI
- https://doi.org/10.3390/biomedicines14040940
- Primary Topic
- Autism Spectrum Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Yüzüncü Yil Üniversitesi