Stable episodic memory and high education do not influence the rate of Alzheimer’s disease pathology as measured by plasma p-tau217

study (n=1005; 1531 samples). The results revealed increases with increasing age over 10 years in p-tau217, where individuals with accelerated episodic-memory decline had the strongest increase. There were no differences in p-tau217 trajectories between individuals with lower or higher education or with well-maintained or age-typical decline in episodic memory. The lack of association with education was further replicated in the independent BioFINDER-2 cohort. These findings underscore the value of plasma p-tau217 for detecting early pathological changes in population-based settings but provide no support that individuals with well-maintained episodic memory or high educational attainment are spared from neuropathological changes.

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Publication Details

Journal
bioRxiv (Cold Spring Harbor Laboratory)
Published
2026-04-21
DOI
https://doi.org/10.64898/2026.04.16.718397
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00

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article

Stable episodic memory and high education do not influence the rate of Alzheimer’s disease pathology as measured by plasma p-tau217

Divya Bali, Sebastian Palmqvist, Annelie Nordin Adolfsson, Niklas Mattsson et al.
bioRxiv (Cold Spring Harbor Laboratory)
Dementia and Cognitive Impairment Research
article

Stable episodic memory and high education do not influence the rate of Alzheimer’s disease pathology as measured by plasma p-tau217

Divya Bali, Sebastian Palmqvist, Annelie Nordin Adolfsson, Niklas Mattsson, Nicola Spotorno, Anna Orduña Dolado, Lars Nyberg, Bárbara Avelar‐Pereira, Shorena Janelidze, Oskar Hansson
article en

Abstract

study (n=1005; 1531 samples). The results revealed increases with increasing age over 10 years in p-tau217, where individuals with accelerated episodic-memory decline had the strongest increase. There were no differences in p-tau217 trajectories between individuals with lower or higher education or with well-maintained or age-typical decline in episodic memory. The lack of association with education was further replicated in the independent BioFINDER-2 cohort. These findings underscore the value of plasma p-tau217 for detecting early pathological changes in population-based settings but provide no support that individuals with well-maintained episodic memory or high educational attainment are spared from neuropathological changes.

bioRxiv (Cold Spring Harbor Laboratory)
Stockholm University (SE), Lund University (SE), Karolinska Institutet (SE), Skåne University Hospital (SE), Umeå University (SE), Stanford University (US)
Michael J. Fox Foundation for Parkinson's Research, Alzheimer's Association, Eli Lilly and Company, Australian Government, GHR Foundation, Lunds Universitet, Knut och Alice Wallenbergs Stiftelse, Vetenskapsrådet, Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse, Skånes universitetssjukhus, Stiftelsen Bundy Academy, Parkinsonfonden
Quality Education
Openalex Percentile: Top 15%
Dementia and Cognitive Impairment Research
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