Genome Mining of <i>Sphingopyxis</i> sp. MG Uncovers an Enzyme with Dual Catalytic Activity of Haloalkane Dehalogenase and Epoxide Hydrolase
HldB has dual EH and Hld promiscuous catalytic activity in its native form. It seems to be a generalist epoxide hydrolase on its way to transit to a specialist Hld.
Authors
- Santosh Kumar Padhi (ORCID: https://orcid.org/0000-0001-5202-6702)
- Annapoorni Lakshman Sagar
- Dayananda Siddavattam (ORCID: https://orcid.org/0000-0002-9437-717X)
- Wenhao Deng
- Yuji Nagata (ORCID: https://orcid.org/0000-0002-9351-139X)
- Ghufrana Abdus Sami
Institutions
- University of Life Sciences in Lublin (PL)
- Tohoku University (JP)
- University of Hyderabad (IN)
- Life University (US)
Publication Details
- Journal
- ACS Chemical Biology
- Published
- 2026-04-20
- DOI
- https://doi.org/10.1021/acschembio.5c00763
- Primary Topic
- Microbial bioremediation and biosurfactants
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department of Biotechnology, Ministry of Science and Technology, India
- Department of Science and Technology, Ministry of Science and Technology, India
- University Grants Commission
- Ministry of Education, India
- Science and Engineering Research Board