Discovery of Highly Potent Phthalazinone Derivatives as PARP14 Inhibitors: From Structure-Based Virtual Screening to <i>In Vivo</i> Pharmacodynamic Activity

Authors

J Liu
Yi Zou (ORCID: https://orcid.org/0000-0001-6782-9380)
Qinlong Xu
Qihua Zhu (ORCID: https://orcid.org/0000-0003-4314-4226)
Zhaoxing Chu (ORCID: https://orcid.org/0000-0003-3347-7449)
Shiqi Wu
Hongfeng Gu (ORCID: https://orcid.org/0009-0004-4385-3430)
Kaiyuan Cong
Ziyue Li
Guangwei He
Yan Zhao
Ping Wei
Shaoxue Lou
Xiangying Kong
Li Shao
Yungen Xu (ORCID: https://orcid.org/0000-0001-6586-8482)
Le Qu
Xiaorong Zeng

Institutions

China Pharmaceutical University (CN)
Hefei Design and Research Institute of Coal Industry (China) (CN)
State Key Laboratory of Natural Medicine

Publication Details

Journal: Journal of Medicinal Chemistry
Published: 2026-04-20
DOI: https://doi.org/10.1021/acs.jmedchem.6c00004
Primary Topic: PARP inhibition in cancer therapy
Type: article
Field-Weighted Citation Impact: 0.00

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article

Discovery of Highly Potent Phthalazinone Derivatives as PARP14 Inhibitors: From Structure-Based Virtual Screening to In Vivo Pharmacodynamic Activity

J Liu, Yi Zou, Qinlong Xu, Qihua Zhu et al.

Apr 20, 2026

Journal of Medicinal Chemistry

PARP inhibition in cancer therapy

article

Discovery of Highly Potent Phthalazinone Derivatives as PARP14 Inhibitors: From Structure-Based Virtual Screening to In Vivo Pharmacodynamic Activity

J Liu, Yi Zou, Qinlong Xu, Qihua Zhu, Zhaoxing Chu, Shiqi Wu, Hongfeng Gu, Kaiyuan Cong, Ziyue Li, Guangwei He, Yan Zhao, Ping Wei, Shaoxue Lou, Xiangying Kong, Li Shao, Yungen Xu, Le Qu, Xiaorong Zeng

April 20, 2026article en

Abstract

No abstract available for this paper.

Journal of Medicinal Chemistry

China Pharmaceutical University (CN), Hefei Design and Research Institute of Coal Industry (China) (CN), State Key Laboratory of Natural Medicine

Zero hunger

Openalex Percentile: Top 11%

PARP inhibition in cancer therapy

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