Examining in vivo effects of silychristin, a potent in vitro inhibitor of thyroid hormone transporter MCT8
models to studies in intact organisms, showcasing the importance of selecting appropriate animal models and the best experimental design for assessing effects on human health.
Authors
- Mary E. Gilbert (ORCID: https://orcid.org/0000-0001-8916-8851)
- Josef Köhrle (ORCID: https://orcid.org/0000-0002-9187-9078)
- Jermaine Ford (ORCID: https://orcid.org/0009-0001-3976-1216)
- Kostja Renko (ORCID: https://orcid.org/0000-0003-2050-0961)
- Marta Axelstad
- MaryAnn Hawks
- Ryne Thomas
Institutions
- Oak Ridge Associated Universities (US)
- Research Triangle Park Foundation (US)
- Federal Institute for Risk Assessment (DE)
- Humboldt-Universität zu Berlin (DE)
- Environmental Protection Agency (IE)
- Technical University of Denmark (DK)
Publication Details
- Journal
- Frontiers in Toxicology
- Published
- 2026-04-20
- DOI
- https://doi.org/10.3389/ftox.2026.1796387
- Primary Topic
- Silymarin and Mushroom Poisoning
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Environmental Protection Agency
- Horizon 2020 Framework Programme