CXCL8 greatly enhances neutrophil extracellular traps formation induced by calcium crystals in vitro and in vivo
. These findings identify an unrecognized crosstalk between chemokine signaling and crystal-driven NETosis, providing mechanistic insight into sterile inflammatory diseases including gout, pseudogout, atherosclerosis, and pancreatitis, and supporting the concept that antagonists of CXCL8 receptors (CXCR1/2) could limit pathological NET formation.
Authors
- Francesco Petragnano (ORCID: https://orcid.org/0000-0003-0118-2435)
- Roberto Maggio (ORCID: https://orcid.org/0000-0003-4436-2356)
- Nicola Detta (ORCID: https://orcid.org/0009-0007-0877-9839)
- Lucia Apparente
- Mario Rossi (ORCID: https://orcid.org/0000-0001-7004-0225)
- Pier Giorgio Amendola (ORCID: https://orcid.org/0000-0002-1476-1287)
- Giada Cremonesi
- Chayakorn Petchakup (ORCID: https://orcid.org/0000-0002-6948-7932)
- Ida Cerqua (ORCID: https://orcid.org/0000-0002-4363-7728)
- Irene Fasciani (ORCID: https://orcid.org/0000-0002-0345-082X)
- Gemma Conte
- Rafael C. Dutra (ORCID: https://orcid.org/0000-0002-6938-2161)
- Marcello Allegretti (ORCID: https://orcid.org/0000-0002-0617-0233)
- Gabriella Aloisi (ORCID: https://orcid.org/0000-0003-2722-6459)
- Andrea Aramini (ORCID: https://orcid.org/0000-0001-8390-6614)
- Riccardo Bertini
- H W Hou
- Maria De Lucia
- Raffaele Capasso
Institutions
- Nanyang Technological University (SG)
- University of L'Aquila (IT)
- American Pharmacists Association (US)
- Dompé (Italy) (IT)
- University of Naples Federico II (IT)
- Fresenius Kabi (Czechia) (CZ)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-04-20
- DOI
- https://doi.org/10.3389/fphar.2026.1794524
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00