Extracellular Vesicle-Associated miR-222-3p and miR-186-5p as Potential Hypoxic Markers in Canine Osteosarcoma: A Preliminary In Vitro Study
≤ 0.05). TargetScan and pathway enrichment analyses demonstrated that miR-186-5p regulates target genes involved in different cellular processes. In human osteosarcoma, low serum levels of miR-222-3p are associated with poor prognosis, while miR-186-5p is recognized as a key hypoxia-responsive miRNA. Collectively, these results suggest the potential of EV-associated miRNAs as biomarkers in canine OSA and support their relevance in translational and comparative oncology.
Authors
- Raffaella De Maria (ORCID: https://orcid.org/0000-0002-7028-2280)
- Lorenza Parisi (ORCID: https://orcid.org/0000-0001-6684-6859)
- Eugenio Mazzone (ORCID: https://orcid.org/0009-0001-6161-5311)
- Federica Fratini (ORCID: https://orcid.org/0000-0003-0807-930X)
- Luiza Cesar Conti (ORCID: https://orcid.org/0009-0005-9146-1869)
- Sara Divari (ORCID: https://orcid.org/0000-0002-6085-0336)
- Manuela Poncina
- Luca Aresu (ORCID: https://orcid.org/0000-0002-7893-1740)
- Lorella Maniscalco (ORCID: https://orcid.org/0000-0001-5504-7218)
- Sonia Capellero (ORCID: https://orcid.org/0000-0001-9043-9014)
Institutions
- National Institute of Health (AM)
- Candiolo Cancer Institute (IT)
- Fondazione Piemontese per la Ricerca sul Cancro Onlus (IT)
- University of Turin (IT)
Publication Details
- Journal
- Animals
- Published
- 2026-04-20
- DOI
- https://doi.org/10.3390/ani16081265
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00