Immunopeptidome profiling in pulmonary fibrosis provides a platform for identifying therapeutic targets
elicited specific human cytotoxic T lymphocytes that lysed human idiopathic pulmonary fibrosis-derived myofibroblasts and M2-like macrophages. This study indicates that immunopeptidome profiling provides a robust platform for discovering translatable antifibrotic immunotherapies.
Authors
- Jiayuan Ai (ORCID: https://orcid.org/0000-0003-2265-4227)
- Charles A. Powell (ORCID: https://orcid.org/0000-0003-3509-891X)
- Haiying Que (ORCID: https://orcid.org/0000-0002-3994-8857)
- Haohao Dong (ORCID: https://orcid.org/0000-0002-5022-3494)
- 袁勇
- Dandan Wan
- Lunzhi Dai (ORCID: https://orcid.org/0000-0002-3003-8910)
- XJ Xiao
- Qiang Pu (ORCID: https://orcid.org/0000-0001-7221-0259)
- Jiayu Wang (ORCID: https://orcid.org/0000-0003-2509-4579)
- Xi Zhang (ORCID: https://orcid.org/0000-0002-4638-3997)
- Liu Y (ORCID: https://orcid.org/0009-0004-3901-1652)
- Ziyi Bai (ORCID: https://orcid.org/0009-0004-5917-5400)
- Tianxia Lan
- Huang
- Qiaonan Hong
- Luca Richeldi
- Chengjian Zhao
- Xiawei Wei (ORCID: https://orcid.org/0000-0002-6513-6422)
- Min Zhu
- Chengxin Xiao
- Xin Wang
- Heng Xu (ORCID: https://orcid.org/0000-0002-7748-2621)
- Weiqi Hong (ORCID: https://orcid.org/0000-0003-1668-2301)
- Fengming Luo
- Ting Yang
Institutions
- Università Cattolica del Sacro Cuore (IT)
- Sichuan University (CN)
- Agostino Gemelli University Polyclinic (IT)
- West China Hospital of Sichuan University (CN)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Nature Immunology
- Published
- 2026-04-20
- DOI
- https://doi.org/10.1038/s41590-026-02501-x
- Citations
- 1
- Primary Topic
- vaccines and immunoinformatics approaches
- Type
- article
- Field-Weighted Citation Impact
- 12.01