MCT4 deficiency suppresses tumor incidence and metastasis by downregulating IGF1 expression and enhancing anti-tumor immunity
mice develop fewer and smaller lesions, underscoring its critical role in tumor incidence. Collectively, these findings identify MCT4 as a key driver of carcinogenesis through IGF1 regulation and immune modulation, highlighting its therapeutic potential.
Authors
- Shuo Wang (ORCID: https://orcid.org/0000-0002-6275-9675)
- Y Zhang
- Hailing Guo (ORCID: https://orcid.org/0000-0002-5211-5462)
- Xinyi Wang (ORCID: https://orcid.org/0000-0002-6926-5934)
- Lujin Feng
- Xin Li
Institutions
- Shenyang Pharmaceutical University (CN)
Publication Details
- Journal
- Communications Biology
- Published
- 2026-04-20
- DOI
- https://doi.org/10.1038/s42003-026-10002-8
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Key Research and Development Program of China