One-Pot Access to Indenones via Ru-Catalyzed C–H Alkenylation and FeCl <sub>3</sub> -Promoted Cyclization
-mediated formal [2 + 2] cycloaddition/ring-opening cascade, delivering diverse indenone derivatives in good to excellent yields with broad functional group tolerance. Mechanistic studies support the formation of an ortho-keto-cinnamate that undergoes Lewis acid-promoted enolate formation, cyclization, and rearomatization. This step and atom-economical protocol offer a practical alternative to conventional indenone syntheses and a versatile platform for late-stage functionalization.
Authors
- Arsheed A. Bhat
- Dattatraya H. Dethe (ORCID: https://orcid.org/0000-0003-2734-210X)
Institutions
- Indian Institute of Technology Kanpur (IN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-04-20
- DOI
- https://doi.org/10.1021/acs.joc.6c00462
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Indian Institute of Technology Kanpur