Cibisatamab and FAP-4-1BBL in microsatellite-stable colorectal cancer: a phase 1b trial
T cell infiltration. These findings demonstrate the feasibility of combining tumor antigen-directed T cell engagement with localized co-stimulation, with evidence of immune activation and preliminary antitumor activity supporting further clinical development. ClinicalTrials.gov identifier: NCT04826003 .
Authors
- Víctor Moreno (ORCID: https://orcid.org/0000-0001-6099-4236)
- Iosune Baraibar (ORCID: https://orcid.org/0000-0002-3500-9641)
- Fiona Thistlethwaite (ORCID: https://orcid.org/0000-0002-4832-7008)
- Tamara Tanos (ORCID: https://orcid.org/0000-0002-3217-3104)
- Iakov I. Davydov (ORCID: https://orcid.org/0000-0003-3510-3926)
- Ignacio Melero (ORCID: https://orcid.org/0000-0002-1360-348X)
- Christian Heichinger
- Pablo Umaña (ORCID: https://orcid.org/0000-0001-8206-2771)
- Seung‐Hoon Beom (ORCID: https://orcid.org/0000-0001-7036-3753)
- Christine McIntyre
- Lining Chen (ORCID: https://orcid.org/0009-0009-5796-922X)
- Ernesto Guarin
- Axel Boehnke
- Maria del Carmen Riesco
- Tulun Saylan
- Victoria Woodcock
- Heather Hinton
- Emiliano Calvo Aller
- Camilla Qvortrup
- Marloes van Dongen
- María Araceli Frutos García (ORCID: https://orcid.org/0000-0001-5891-3935)
- Tae Jeong Kim (ORCID: https://orcid.org/0000-0001-9522-1997)
Institutions
- Ulsan College (KR)
- Roche (Switzerland) (CH)
- Hebron University (PS)
- Yonsei University (KR)
- Asan Medical Center (KR)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- University of Manchester (GB)
- The Netherlands Cancer Institute (NL)
- University of Oxford (GB)
- University of Ulsan (KR)
- Hospital Universitario 12 De Octubre (ES)
- Vall d'Hebron Institut de Recerca (ES)
- Roche (United Kingdom) (GB)
- Vall d'Hebron Hospital Universitari (ES)
- Hospital Universitario Fundación Jiménez Díaz (ES)
- Hospital Del Mar (ES)
- The Christie NHS Foundation Trust (GB)
- Clinica Universidad de Navarra (ES)
- Oxford University Hospitals NHS Trust (GB)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
Publication Details
- Journal
- Nature Medicine
- Published
- 2026-04-20
- DOI
- https://doi.org/10.1038/s41591-026-04380-z
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- F. Hoffmann-La Roche