Cibisatamab and FAP-4-1BBL in microsatellite-stable colorectal cancer: a phase 1b trial

T cell infiltration. These findings demonstrate the feasibility of combining tumor antigen-directed T cell engagement with localized co-stimulation, with evidence of immune activation and preliminary antitumor activity supporting further clinical development. ClinicalTrials.gov identifier: NCT04826003 .

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Publication Details

Journal
Nature Medicine
Published
2026-04-20
DOI
https://doi.org/10.1038/s41591-026-04380-z
Primary Topic
Peptidase Inhibition and Analysis
Type
article
Field-Weighted Citation Impact
0.00

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article

Cibisatamab and FAP-4-1BBL in microsatellite-stable colorectal cancer: a phase 1b trial

Víctor Moreno, Iosune Baraibar, Fiona Thistlethwaite, Tamara Tanos et al.
Nature Medicine
Peptidase Inhibition and Analysis
article

Cibisatamab and FAP-4-1BBL in microsatellite-stable colorectal cancer: a phase 1b trial

Víctor Moreno, Iosune Baraibar, Fiona Thistlethwaite, Tamara Tanos, Iakov I. Davydov, Ignacio Melero, Christian Heichinger, Pablo Umaña, Seung‐Hoon Beom, Christine McIntyre, Lining Chen, Ernesto Guarin, Axel Boehnke, Maria del Carmen Riesco, Tulun Saylan, Victoria Woodcock, Heather Hinton, Emiliano Calvo Aller, Camilla Qvortrup, Marloes van Dongen, María Araceli Frutos García, Tae Jeong Kim
article en

Abstract

T cell infiltration. These findings demonstrate the feasibility of combining tumor antigen-directed T cell engagement with localized co-stimulation, with evidence of immune activation and preliminary antitumor activity supporting further clinical development. ClinicalTrials.gov identifier: NCT04826003 .

Nature Medicine
Ulsan College (KR), Roche (Switzerland) (CH), Hebron University (PS), Yonsei University (KR), Asan Medical Center (KR), Copenhagen University Hospital (DK), Rigshospitalet (DK), University of Manchester (GB), The Netherlands Cancer Institute (NL), University of Oxford (GB), University of Ulsan (KR), Hospital Universitario 12 De Octubre (ES), Vall d'Hebron Institut de Recerca (ES), Roche (United Kingdom) (GB), Vall d'Hebron Hospital Universitari (ES), Hospital Universitario Fundación Jiménez Díaz (ES), Hospital Del Mar (ES), The Christie NHS Foundation Trust (GB), Clinica Universidad de Navarra (ES), Oxford University Hospitals NHS Trust (GB), Centro de Investigación Biomédica en Red de Cáncer (ES)
F. Hoffmann-La Roche
Good health and well-being
Openalex Percentile: Top 18%
Peptidase Inhibition and Analysis
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