A Novel Ocellatin-P1 Isoform from Leptodactylus labyrinthicus Frog Skin Secretion: Purification, Biological Properties and Three-Dimensional Structure
, which remains largely preserved even at 95 °C. NMR Hydrogen/Deuterium (H/D) exchange experiments suggest that ocellatin-LB3 adopts a preferential orientation when interacting with SDS micelles. Based on the similarity among ocellatins, and on the physicochemical and structural properties of this peptide, a possible membrane-mediated mode of action is proposed, although this remains to be experimentally validated.
Authors
- Alice da Cunha Morales Álvares
- César Augusto Prías-Márquez
- Wagner Fontes (ORCID: https://orcid.org/0000-0001-5140-8573)
- Ricardo Bentes Azevedo (ORCID: https://orcid.org/0000-0002-2137-9588)
- E.S.F. Alves (ORCID: https://orcid.org/0000-0003-2091-4443)
- Osmindo Rodrigues Pires Júnior (ORCID: https://orcid.org/0000-0002-9875-9407)
- Rafael Marques Porto
- Luciano M. Lião (ORCID: https://orcid.org/0000-0001-9985-2980)
- Alexandra Maria dos Santos Carvalho (ORCID: https://orcid.org/0000-0002-3317-9479)
- Mariana S. Castro (ORCID: https://orcid.org/0000-0001-5143-152X)
- Fabiano José Queiroz Costa (ORCID: https://orcid.org/0000-0002-9345-0275)
- Eduardo Maffud Cilli (ORCID: https://orcid.org/0000-0002-4767-0904)
- Aline Oliveira (ORCID: https://orcid.org/0000-0002-6928-078X)
- Sônia Maria de Freitas (ORCID: https://orcid.org/0000-0002-7562-4980)
- Carlos José Correia de Santana (ORCID: https://orcid.org/0000-0001-9781-3670)
- Izabela Marques Dourado Bastos (ORCID: https://orcid.org/0000-0002-2785-4255)
- Isabel de Fátima Correia Batista (ORCID: https://orcid.org/0000-0001-7398-4184)
- Isabelle S. Luz
- Felipe da Silva Mendonça de Melo
- Henrique de Oliveira Noronha
- João Paulo Stawiarski Miranda
- Marco Antônio Damasceno Faustino (ORCID: https://orcid.org/0009-0001-1221-0043)
Institutions
- Universidade de Brasília (BR)
- Instituto Butantan (BR)
- Instituto de Saúde (BR)
- Rede de Química e Tecnologia (PT)
- Universidade Federal de Goiás (BR)
- Universidade Estadual Paulista (Unesp) (BR)
Publication Details
- Journal
- International Journal of Molecular Sciences
- Published
- 2026-04-20
- DOI
- https://doi.org/10.3390/ijms27083658
- Primary Topic
- Antimicrobial Peptides and Activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Empreendimentos Científicos e Tecnológicos