18F-FDG Uptake Outperforms 68Ga-FAPI-04 in Papillary Renal Neoplasm With Reverse Polarity

Papillary renal neoplasm with reverse polarity (PRNRP) is very rare. Herein, we report a case of imaging findings of PRNRP in a 75-year-old woman. On the 68Ga-FAPI-04 PET/CT and 18F-FDG PET/CT image, it presented as a soft-tissue nodule in the left renal pelvis with intense FDG uptake (SUVmax: 20.8) but no FAPI uptake. Postsurgical pathology supported a diagnosis of PRNRP.

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Publication Details

Journal
Clinical Nuclear Medicine
Published
2026-04-13
DOI
https://doi.org/10.1097/rlu.0000000000006494
Primary Topic
Peptidase Inhibition and Analysis
Type
article
Field-Weighted Citation Impact
0.00
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article

18F-FDG Uptake Outperforms 68Ga-FAPI-04 in Papillary Renal Neoplasm With Reverse Polarity

Lin Li, Liu Xiao, Lu Yao
Clinical Nuclear Medicine
Peptidase Inhibition and Analysis
article

18F-FDG Uptake Outperforms 68Ga-FAPI-04 in Papillary Renal Neoplasm With Reverse Polarity

Lin Li, Liu Xiao, Lu Yao
article en

Abstract

Papillary renal neoplasm with reverse polarity (PRNRP) is very rare. Herein, we report a case of imaging findings of PRNRP in a 75-year-old woman. On the 68Ga-FAPI-04 PET/CT and 18F-FDG PET/CT image, it presented as a soft-tissue nodule in the left renal pelvis with intense FDG uptake (SUVmax: 20.8) but no FAPI uptake. Postsurgical pathology supported a diagnosis of PRNRP.

Clinical Nuclear Medicine
Sichuan University (CN), West China Hospital of Sichuan University (CN)
Good health and well-being
Openalex Percentile: Top 11%
Peptidase Inhibition and Analysis
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