Critical Role for Malic Enzymes in MYC-Mediated Cellular Adaptation to Glutamine Depletion
ME1 and ME2 support metabolic adaptation to glutamine starvation through distinct, isoform-specific mechanisms that depend on MYC expression and p53 mutation status. These findings suggest malic enzymes as potential therapeutic targets in MYC-driven, p53-mutant tumors.
Authors
- Chenrui Hu
- Wenhua Li (ORCID: https://orcid.org/0000-0002-9457-6662)
- Jiayang Yuan
- Yufan Si
- Yang Chen
- Yanan Liu
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Publication Details
- Journal
- Metabolites
- Published
- 2026-04-20
- DOI
- https://doi.org/10.3390/metabo16040282
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- National Natural Science Foundation of China