Clinical Outcomes and Patterns of Neurological Toxicity After Stereotactic Body Radiotherapy Reirradiation (reSBRT) of Spine Metastases Previously Treated with SBRT
BACKGROUND/OBJECTIVES: Stereotactic body radiation therapy (SBRT) provides improved pain response and local control for spinal metastases. However, management of local failure after initial SBRT is challenging. We report institutional outcomes, dosimetry, and toxicity for reSBRT following SBRT. METHODS: ) using the linear-quadratic model (α/β = 2). RESULTS: > 108 Gy. CONCLUSIONS: ReSBRT provided a favorable LC with acceptable toxicity. High cumulative dose to the thecal sac and nerve roots may contribute to neurologic toxicity as peripheral nerve injury.
Authors
- Arnab Chakravarti (ORCID: https://orcid.org/0000-0002-5392-8721)
- Mark Addington
- Eric C. Bourekas
- Dukagjin M. Blakaj (ORCID: https://orcid.org/0000-0002-1718-9642)
- Sasha Beyer (ORCID: https://orcid.org/0000-0001-5651-6581)
- Simeng Zhu (ORCID: https://orcid.org/0000-0003-0850-6690)
- D.J. DiCostanzo (ORCID: https://orcid.org/0000-0002-3222-7141)
- Eugene T. Yap (ORCID: https://orcid.org/0000-0003-3973-8195)
- J. Bradley Elder (ORCID: https://orcid.org/0000-0002-6650-3271)
- Katelyn Fernando
- Brian Park
- Joshua D. Palmer
- E. Cochran
- David J. Konieczkowski
- Raj Singh
- Khaled N. Dibs
- Daniel Boulter
- Russell Lonser
- Robyn Handschuh
- Daniel Schneider
- Ahmed N. Elguindy (ORCID: https://orcid.org/0009-0005-1316-0809)
- Raju Raval
- John C. Grecula
Institutions
- Ain Shams University (EG)
- The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US)
- The Ohio State University Wexner Medical Center (US)
- Ain Shams University Hospital (EG)
Publication Details
- Journal
- Cancers
- Published
- 2026-04-20
- DOI
- https://doi.org/10.3390/cancers18081301
- Primary Topic
- Management of metastatic bone disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00