Boronic Acid-Assisted Site-Selective Benzylation of Unprotected Saccharides
Site-selective benzylation of specific hydroxyl groups (OH) in unprotected saccharides is crucial for the synthesis of complex saccharide-based pharmaceuticals. However, it remains a significant challenge due to the minimal reactivity differences among multiple chemically similar OH groups. Herein, we present a site-switchable, one-step synthetic benzylation strategy through strategically tuning the structure of boronic acids. This general and practical strategy establishes a framework for the rapid assembly of structurally diverse saccharide derivatives.
Authors
- Wen‐Xin Lv (ORCID: https://orcid.org/0000-0002-9114-4258)
- Shiqing Huang (ORCID: https://orcid.org/0000-0002-6377-368X)
- Haiqi Wang (ORCID: https://orcid.org/0000-0001-6952-4054)
- Yonggui Robin (ORCID: https://orcid.org/0000-0003-0573-257X)
- Chang Chin Ho
- Liang Yang (ORCID: https://orcid.org/0000-0001-9012-3669)
- Min Xu
Institutions
- Nanyang Technological University (SG)
- Guizhou University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- Shanghai Pesticide Research Institute (CN)
- Renmin University of China (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-04-20
- DOI
- https://doi.org/10.1021/acs.orglett.6c00589
- Primary Topic
- Carbohydrate Chemistry and Synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation Singapore
- Ministry of Education - Singapore
- Nanyang Technological University
- National Natural Science Foundation of China
- Guizhou University
- Higher Education Discipline Innovation Project
- Young Scientists Fund
- National Key Research and Development Program of China