Activatable nanoflytrap achieves synergistic “Capture-Block-Regulate” therapy of pancreatic ductal adenocarcinoma

catalyzed cleavage to generate reactive oxygen species, triggering ferroptosis and mitigating hypoxia induced resistance. Gadolinium integration facilitates MRI guided monitoring. Transcriptomic and metabolomic analyses reveal that NT orchestrates apoptosis and ferroptosis while disturbing lipid metabolism and suppressing angiogenesis through ROS accumulation. This biomimetic capture block regulate strategy effectively overcomes stromal and hypoxic barriers, providing a promising MRI guided theranostic platform for PDAC.