Case Report: Facial-limited eosinophilic annular erythema in a patient with rheumatoid arthritis: successful treatment with tofacitinib

We report a case of a 67-year-old man with rheumatoid arthritis (RA) presenting with symmetrical annular plaques confined to the face. Histopathology demonstrated dense dermal eosinophilia without flame figures, consistent with eosinophilic annular erythema (EAE). Unlike the typical truncal distribution, lesions were limited to the face, a presentation reported in approximately 3% of cases. The patient was successfully treated with tofacitinib, a Janus kinase (JAK) inhibitor. This report illustrates a rare facial variant of EAE and supports the efficacy of JAK inhibition in patients with concurrent RA.

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Publication Details

Journal
Frontiers in Immunology
Published
2026-04-20
DOI
https://doi.org/10.3389/fimmu.2026.1792217
Primary Topic
Eosinophilic Disorders and Syndromes
Type
article
Field-Weighted Citation Impact
0.00

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article

Case Report: Facial-limited eosinophilic annular erythema in a patient with rheumatoid arthritis: successful treatment with tofacitinib

Man-Ning Wu, Yan-Ping Bai, Lei Wang, Ying Wang
Frontiers in Immunology
Eosinophilic Disorders and Syndromes
article

Case Report: Facial-limited eosinophilic annular erythema in a patient with rheumatoid arthritis: successful treatment with tofacitinib

Man-Ning Wu, Yan-Ping Bai, Lei Wang, Ying Wang
article en

Abstract

We report a case of a 67-year-old man with rheumatoid arthritis (RA) presenting with symmetrical annular plaques confined to the face. Histopathology demonstrated dense dermal eosinophilia without flame figures, consistent with eosinophilic annular erythema (EAE). Unlike the typical truncal distribution, lesions were limited to the face, a presentation reported in approximately 3% of cases. The patient was successfully treated with tofacitinib, a Janus kinase (JAK) inhibitor. This report illustrates a rare facial variant of EAE and supports the efficacy of JAK inhibition in patients with concurrent RA.

Frontiers in ImmunologyVol. 17
Beijing University of Chinese Medicine (CN), China-Japan Friendship Hospital (CN)
China-Japan Friendship Hospital
Good health and well-being
Openalex Percentile: Top 23%
Eosinophilic Disorders and Syndromes
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