Case Report: Facial-limited eosinophilic annular erythema in a patient with rheumatoid arthritis: successful treatment with tofacitinib
We report a case of a 67-year-old man with rheumatoid arthritis (RA) presenting with symmetrical annular plaques confined to the face. Histopathology demonstrated dense dermal eosinophilia without flame figures, consistent with eosinophilic annular erythema (EAE). Unlike the typical truncal distribution, lesions were limited to the face, a presentation reported in approximately 3% of cases. The patient was successfully treated with tofacitinib, a Janus kinase (JAK) inhibitor. This report illustrates a rare facial variant of EAE and supports the efficacy of JAK inhibition in patients with concurrent RA.
Authors
- Man-Ning Wu (ORCID: https://orcid.org/0000-0002-2154-1258)
- Yan-Ping Bai
- Lei Wang
- Ying Wang
Institutions
- Beijing University of Chinese Medicine (CN)
- China-Japan Friendship Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-04-20
- DOI
- https://doi.org/10.3389/fimmu.2026.1792217
- Primary Topic
- Eosinophilic Disorders and Syndromes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China-Japan Friendship Hospital