Evaluation of total serum Immunoglobulin E level in leukemia patients infected with parasite infection in Kirkuk City

Naturally occurring human immunity to parasitic infection has been associated with Immunoglobulin E (IgE) responses against parasite allergen-like proteins. However, parasites are known to exert strong immunomodulatory effects; including regulatory cells and cytokines. Elevated IgE levels often lead to the elimination of parasites and the removal of poisons from the body. This study aimed to measure the total serum IgE levels in 100 leukemia patients with and without parasitic infection. (100) blood samples from leukemia patients after chemotherapy were used in this study. This study was carried out between September 2023 and May 2024, at Kirkuk Oncology and Hematology Center and Kirkuk General Hospital to determine the total IgE level in serum. We have noticed the presence of different types of parasites in 52 samples with leukaemia disease, the most prominent was (protozoa)Entamoeba histolytica, Blastocyst hominis, and others, (helminths) Ascaris lumbricoides, Entrobius vermicularis and seropositive toxoplasma gondii immunoglobulin G (IgG)and (48) samples that do not contain parasites. However, the mean IgE concentration in leukemia patients infected with parasites was higher (199.59ng/ml) compared to non-infected leukemia and controls at146.56ng/ml, and 49.9ng/ml respectively. The study proved that IgE levels increased in parasitic infection in leukemia patients after chemotherapy.