Gender-specific Relationship between Serum Uric Acid to Serum Creatinine Ratio and Prognosis after Cerebral Venous Sinus Thrombosis

INTRODUCTION: Serum Uric Acid to Serum Creatinine Ratio (SUA/SCr) is a new indicator for evaluating renal function and has been found to be associated with multiple prognostic outcomes. This study explores the association between SUA/SCr and prognosis in patients with Cerebral Venous Sinus Thrombosis (CVST). METHODS: Retrospectively analyze the patients with CVST admitted to the First Affiliated Hospital of Zhengzhou University from January 2011 to October 2023. The modified Rankin Scale (mRS) is used to evaluate the functional outcomes of the patients. Multivariate logistic regression analysis is adopted to assess the relationship between SUA/SCr and the functional outcomes after CVST. RESULTS: Male patients had higher levels of SUA and SCr than females. Multivariate logistic regression analysis showed that each 1 μ mol/L increase in SUA/SCr levels was linked to lower risks of poor prognosis (OR 0.781, 95% CI 0.621 - 0.982, P = 0.034) and mortality (OR 0.647, 95% CI 0.468 - 0.895, P = 0.009) for females. When categorized by SUA/SCr quartiles, compared with the lowest quartile of SUA/SCr, the highest and the second highest quartiles of SUA/SCr were associated with a 0.344-fold (0.107 - 1.101) and 0.837-fold (0.366 - 1.914) lower risk of poor prognosis, as well as a 0.076-fold (0.009 - 0.658) and 0.510-fold (0.192 - 1.356) lower risk of mortality in females. DISCUSSION: SUA/SCr levels may be a predictor of adverse clinical outcomes and mortality in patients with CVST, and this protective association is gender-specific. CONCLUSION: Higher SUA/SCr levels were associated with better prognosis in females.