Molnupiravir Treatment Associated with Clearance of Cache Valley Virus from Cerebrospinal Fluid in an Immunocompromised Child with Meningoencephalitis
Abstract Cache Valley virus (CVV) is a bunyavirus endemic to North America, commonly infecting livestock, but known to cause meningoencephalitis in immunocompromised humans in rare cases. We present the first known pediatric case of CVV encephalitis in an adolescent with IKZF1/Ikaros immunodeficiency with viral clearance from cerebrospinal fluid (CSF) after molnupiravir antiviral therapy.
Authors
- Amitha Ananth (ORCID: https://orcid.org/0000-0002-9671-2883)
- David W. Kimberlin (ORCID: https://orcid.org/0000-0001-9038-9109)
- Charles Y. Chiu (ORCID: https://orcid.org/0000-0003-2915-2094)
- Lydia Marcus (ORCID: https://orcid.org/0000-0003-2725-2825)
- Claire McDonald
- T Prescott Atkinson
- Destini Smith Byrd
Institutions
- University of California, San Francisco (US)
- Vanderbilt University (US)
- University of Alabama at Birmingham (US)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2026-04-16
- DOI
- https://doi.org/10.1093/ofid/ofag217
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00