Phosphorescent Iridium Hydrazinonicotinic Acid (HYNIC) Complexes That Bind to Prostate Specific Membrane Antigen: Potential Photodynamic Therapy of Prostate Cancer
is nontoxic to cells in the dark, but irradiation with visible light results in a dose-dependent cytotoxicity. These complexes have the potential to be of use to identify tumor margins, to guide robot-assisted surgical resection of tumors, as well as for molecularly targeted PDT.
Authors
- Katherine A. Morgan (ORCID: https://orcid.org/0000-0002-2874-8737)
- Jonathan M. White
- Stacey E. Rudd (ORCID: https://orcid.org/0000-0001-9996-8561)
- T J S SMITH
- Emily R. McGowan
- Paul S. Donnelly (ORCID: https://orcid.org/0000-0001-5373-0080)
- La'El Kimchi
Institutions
- Biotechnology Institute (US)
- The University of Melbourne (AU)
Publication Details
- Journal
- Chemistry - A European Journal
- Published
- 2026-04-17
- DOI
- https://doi.org/10.1002/chem.71011
- Primary Topic
- Photodynamic Therapy Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Australian Cancer Research Foundation
- Australian Research Council
- National Health and Medical Research Council