Maternal Cytomegalovirus Serology Results by Geographic Region in a Large Multicenter US Study
Congenital cytomegalovirus (CMV) infection, due to both nonprimary and primary maternal infection, affects nearly 1% of neonates. In conducting a randomized trial of hyperimmune globulin for prevention of congenital CMV infection, we screened over 200,000 pregnancies across the United States for evidence of prior or primary CMV infection and evaluated their geographic variation. Although the majority were seropositive, seroprevalence and primary infection risk varied significantly by geographic region, with seroprevalence the highest (88%) and primary infection (0.2%) the lowest in the Southwest. This variation in seroprevalence by geography may inform planning of public health measures to decrease congenital CMV.
Authors
- Cora MacPherson (ORCID: https://orcid.org/0009-0002-8868-4912)
- Maged M. Costantine (ORCID: https://orcid.org/0000-0003-4076-469X)
- G. Mallett
- Edward K. Chien (ORCID: https://orcid.org/0000-0003-3268-0111)
- Brenna L. Hughes (ORCID: https://orcid.org/0000-0001-8950-1204)
- Suneet P. Chauhan (ORCID: https://orcid.org/0000-0003-1093-4416)
- Kent Heyborne (ORCID: https://orcid.org/0000-0002-2251-8367)
- G Swamy
- George A. Macones (ORCID: https://orcid.org/0000-0002-1164-3568)
- Brian M. Casey (ORCID: https://orcid.org/0000-0001-5452-3761)
- Cynthia Gyamfi‐Bannerman (ORCID: https://orcid.org/0000-0002-3026-2277)
- William Goodnight (ORCID: https://orcid.org/0000-0001-8813-6743)
- Peter G. Napolitano
- Mara J. Dinsmoor (ORCID: https://orcid.org/0000-0002-4643-8871)
- Michael W. Varner (ORCID: https://orcid.org/0000-0001-9455-3973)
- Rebecca G. Clifton
- G Saade
- Yasser Y. El‐Sayed
- Samuel Parry (ORCID: https://orcid.org/0000-0002-5946-9247)
- Robert Pass
- Uma M Reddy
- Alan T N Tita (ORCID: https://orcid.org/0000-0002-7244-9056)
- Hyagriv N Simhan
- Donna Allard
- Dwight J Rouse
Institutions
- Northwestern University (US)
- University of North Carolina at Chapel Hill (US)
- Memorial Hermann (US)
- Madigan Army Medical Center (US)
- University of Pittsburgh (US)
- Duke University (US)
- George Washington University (US)
- University of Utah (US)
- Brown University (US)
- Columbia University Irving Medical Center (US)
- Hospital of the University of Pennsylvania (US)
- University of Alabama at Birmingham (US)
- Northwestern University (PH)
- Utah Department of Health (US)
- Stanford Medicine (US)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (US)
- Northwestern Medicine (US)
- University of Utah Health Care (US)
- Duke University Hospital (US)
- University of Colorado Anschutz Medical Campus (US)
- The Ohio State University (US)
- The University of Texas Medical Branch at Galveston (US)
- Case Western Reserve University (US)
- Columbia University (US)
- University of Pennsylvania (US)
- The University of Texas at Austin (US)
- The University of Texas Southwestern Medical Center (US)
- Stanford University (US)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2026-04-16
- DOI
- https://doi.org/10.1093/infdis/jiag224
- Primary Topic
- Cytomegalovirus and herpesvirus research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fonds de dotation CSL Behring pour la recherche
- National Center for Advancing Translational Sciences
- Eunice Kennedy Shriver National Institute of Child Health and Human Development