An Uncommon Presentation of a Solid Pseudopapillary Neoplasm in a Male Patient: Diagnostic Challenges and Multidisciplinary Management of a Pancreatic Tail Mass

Solid pseudopapillary neoplasm (SPN) is a rare pancreatic tumor that typically affects young women and has a low malignant potential. We report the case of a 37-year-old man who was being investigated for secondary hypertension when imaging revealed a pancreatic tail mass. Radiological findings suggested a differential diagnosis including SPN, cystic adenocarcinoma, or a mesenchymal tumor. Further evaluation with MRI, PET, and histopathology confirmed the diagnosis of SPN. The patient underwent successful robotic distal pancreatectomy with splenectomy and was found to have an R0 resection with no nodal involvement. This case highlights the importance of a multidisciplinary approach and maintaining a broad differential diagnosis, even in atypical patient populations.

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Publication Details

Journal
Cureus
Published
2026-04-17
DOI
https://doi.org/10.7759/cureus.107270
Primary Topic
Pancreatic and Hepatic Oncology Research
Type
article
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article

An Uncommon Presentation of a Solid Pseudopapillary Neoplasm in a Male Patient: Diagnostic Challenges and Multidisciplinary Management of a Pancreatic Tail Mass

Mohamed Lameir Mukhtar Hussein, Rana Shalaby, Sarah Sayed, Khadija Jaffar KI Radwani
Cureus
Pancreatic and Hepatic Oncology Research
article

An Uncommon Presentation of a Solid Pseudopapillary Neoplasm in a Male Patient: Diagnostic Challenges and Multidisciplinary Management of a Pancreatic Tail Mass

Mohamed Lameir Mukhtar Hussein, Rana Shalaby, Sarah Sayed, Khadija Jaffar KI Radwani
article en

Abstract

Solid pseudopapillary neoplasm (SPN) is a rare pancreatic tumor that typically affects young women and has a low malignant potential. We report the case of a 37-year-old man who was being investigated for secondary hypertension when imaging revealed a pancreatic tail mass. Radiological findings suggested a differential diagnosis including SPN, cystic adenocarcinoma, or a mesenchymal tumor. Further evaluation with MRI, PET, and histopathology confirmed the diagnosis of SPN. The patient underwent successful robotic distal pancreatectomy with splenectomy and was found to have an R0 resection with no nodal involvement. This case highlights the importance of a multidisciplinary approach and maintaining a broad differential diagnosis, even in atypical patient populations.

Cureus
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Pancreatic and Hepatic Oncology Research
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