Chinese cobra (Naja atra) SVPLA2 promotes muscle inflammation via RPL35A-mediated translational reprogramming
drives pathology via coordinated transcriptional and translational mechanisms, supports varespladib's therapeutic potential, and unveils a non-canonical pro-inflammatory role of RPL35A beyond its ribosomal function, which offers therapeutic possibilities for the treatment of other inflammatory diseases.
Authors
- Yiqin Zeng (ORCID: https://orcid.org/0000-0002-8154-5939)
- Xiaowen Bi
- Jiahao Liu
- Yuji Jin
- Zejing Wen
- Qian Li
- Jiaqi Sun
- Sunkun Tang
- Chunhong Huang (ORCID: https://orcid.org/0009-0007-1097-7842)
- Yang Yang
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- Peking University Shenzhen Hospital (CN)
- Jilin Medical University (CN)
- First Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Communications Biology
- Published
- 2026-04-17
- DOI
- https://doi.org/10.1038/s42003-026-10078-2
- Primary Topic
- Pluripotent Stem Cells Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00