Metabolite import by SLC33A1 is required for ATF6 activation during endoplasmic reticulum stress
-deficient cells. Together, our findings highlight a role of SLC33A1-mediated metabolite transport in the post-ER ATF6α maturation, linking small-molecule metabolism to branch-specific signalling in the UPR.
Authors
- Heather P. Harding (ORCID: https://orcid.org/0000-0002-7359-7974)
- A. Ordóñez (ORCID: https://orcid.org/0000-0003-4239-459X)
- Ginto George (ORCID: https://orcid.org/0000-0003-4804-9594)
- David Ron (ORCID: https://orcid.org/0000-0002-3014-5636)
- Richard Kay
Institutions
- University of Cambridge (GB)
- Wellcome/MRC Institute of Metabolic Science (GB)
- MRC Epidemiology Unit (GB)
- Universidad Católica de Murcia (ES)
Publication Details
- Journal
- Life Science Alliance
- Published
- 2026-04-17
- DOI
- https://doi.org/10.26508/lsa.202603679
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome
- Ministerio de Ciencia, Innovación y Universidades