Bioinspired Engineering of <i>Bombyx mori</i> Silk Fibroin: Solution Blow-Spun Nanofibers Hybridized with (3-Aminopropyl)triethoxysilane
O solution, and hybridized with APTES before fiber production. The resulting nanofibers displayed smooth, uniform morphologies and nanoscale diameters, confirming the effectiveness of SB-spinning for creating hybrid systems. Rheological analyses showed that adding APTES reduced viscosity and enhanced the processability of fibroin solutions. Spectroscopic and X-ray diffraction data revealed an increased β-sheet content and crystallinity in the hybrid fibers, while thermogravimetric analysis indicated improved thermal stability. Overall, these results demonstrate that incorporating APTES effectively alters the physicochemical and structural properties of silk fibroin, enabling the production of promising nanofibrous scaffolds for biomedical applications. This study thus introduces an approach to engineering organic-inorganic hybrid biomaterials via a scalable, low-cost spinning process.
Authors
- Osvaldo N. Oliveira (ORCID: https://orcid.org/0000-0002-5399-5860)
- Caio G. Otoni (ORCID: https://orcid.org/0000-0001-6734-7381)
- Amanda R. Sorigotti (ORCID: https://orcid.org/0000-0002-9721-3111)
- Rafaella F. Fernandes (ORCID: https://orcid.org/0000-0002-0135-8528)
- Róbson Rosa da Silva (ORCID: https://orcid.org/0000-0001-6887-4749)
- Hernane da Silva Barud (ORCID: https://orcid.org/0000-0001-9081-2413)
- Rafaella T. Paschoalin (ORCID: https://orcid.org/0000-0002-8136-2083)
- Luiz Henrique Capparelli Mattoso
- Sidney J. L. Ribeiro
Institutions
- Universidade Federal de São Carlos (BR)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Brazilian Agricultural Research Corporation (BR)
- Institute of Physics (PL)
- Division of Materials Science and Engineering (AU)
- SHL Medical (Switzerland) (CH)
- Hospital Universitário da Universidade de São Paulo (BR)
- Centro Universitário de Araraquara (BR)
- Universidade Estadual Paulista (Unesp) (BR)
Publication Details
- Journal
- ACS Applied Bio Materials
- Published
- 2026-04-17
- DOI
- https://doi.org/10.1021/acsabm.6c00155
- Primary Topic
- Silk-based biomaterials and applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico