Leavening Inspired Synthesis of Mesoporous High‐Entropy Oxide Nanozymes for Detection and Discrimination of Multiple Biological Antioxidants

/g), and well-crystallized frameworks are synthesized, exhibiting oxidase (OXD)-like activities. Leveraging oxidase-like activity, a four-channel colorimetric sensing array is constructed for simultaneous detection and discrimination of five key serum antioxidants: ascorbic acid, glutathione, L-cysteine, uric acid, and tocopherol with range from 10 to 50 µmol/L. The Support Vector Machine algorithm is used, and the accuracy rate reaches 92%. This work provides a universal synthesis strategy for mesoporous HEO nanozymes with tunable compositions and excellent OXD-like activities, showing great potential in complex bioanalytical applications.