Paracrine Induction of Cardiomyogenic Differentiation in Patient-Specific MSCs Using Conditioned Medium from iPSC-CMs
: Although current densities indicate partial immaturity, their reproducible detection validates successful cardiomyogenic commitment. This "parallel differentiation" platform eliminates donor-specific protocol tuning, providing a streamlined, paracrine-mediated approach to generate autologous cardiomyocyte-like cells for disease modeling, pharmacological testing, and future regenerative applications.
Authors
- Dmitriy Shumakov
- В. В. Донцов (ORCID: https://orcid.org/0000-0003-2904-5213)
- Mikhail А. Popov (ORCID: https://orcid.org/0000-0002-0316-8410)
- Sheida Frolova (ORCID: https://orcid.org/0000-0001-5325-8118)
- Alexander Romanov (ORCID: https://orcid.org/0000-0002-6958-6690)
- Dmitriy Zybin
- V. V. Litvinenko
- Konstantin Agladze (ORCID: https://orcid.org/0000-0002-9258-436X)
- М. М. Slotvitsky (ORCID: https://orcid.org/0000-0003-2237-4217)
- Valeriya Tsvelaya
- Serafima Romanova
- Sandaara Kovalenko
- Rose Alkhateeb
- Vitalii Dzhabrailov
- Evgeniy G. Agafonov
Institutions
- Regional Clinical Research (US)
- Meshalkin National Medical Research Center (RU)
Publication Details
- Journal
- Biomedicines
- Published
- 2026-04-17
- DOI
- https://doi.org/10.3390/biomedicines14040919
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Russian Science Foundation
- Ministry of Health of the Russian Federation