Small Diameter Vascular Grafts Made in Minutes

Vascular trauma demands rapid intervention to avert severe outcomes, yet current surgical treatments, including invasive autologous grafts and limited, potentially degrading synthetic prostheses, often fail to accommodate the requirements of variable vessel dimensions and shapes. To address these limitations, we present an additive manufacturing strategy for rapid, point-of-care fabrication of customizable vascular grafts using Focused Rotary Jet Spinning (FRJS). This technique enables the rapid, point-of-care fabrication of customizable small-caliber vascular grafts within minutes. FRJS facilitates independent control over nanofiber alignment and centimeter-scale vessel dimensions, yielding grafts with appropriate mechanical properties and flow characteristics. Four-week in vivo evaluation in a rat femoral vasculature replacement model demonstrated sustained vascular patency and early tissue remodeling, supporting the potential for intraoperative generation of tailored vascular conduits.

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Publication Details

Journal
Advanced Materials
Published
2026-04-16
DOI
https://doi.org/10.1002/adma.202509353
Primary Topic
Electrospun Nanofibers in Biomedical Applications
Type
article
Field-Weighted Citation Impact
0.00

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article

Small Diameter Vascular Grafts Made in Minutes

Yichong Wang, Kevin Kit Parker, Simon P. Hoerstrup, Melanie Generali et al.
Advanced Materials
Electrospun Nanofibers in Biomedical Applications
article

Small Diameter Vascular Grafts Made in Minutes

Yichong Wang, Kevin Kit Parker, Simon P. Hoerstrup, Melanie Generali, Serjosha Robmann, Kirstin Atrott, Michael M. Peters, Debora Meier, Dennis Zorndt, Maximilian Y. Emmert, Yoonseo Lee
article en

Abstract

Vascular trauma demands rapid intervention to avert severe outcomes, yet current surgical treatments, including invasive autologous grafts and limited, potentially degrading synthetic prostheses, often fail to accommodate the requirements of variable vessel dimensions and shapes. To address these limitations, we present an additive manufacturing strategy for rapid, point-of-care fabrication of customizable vascular grafts using Focused Rotary Jet Spinning (FRJS). This technique enables the rapid, point-of-care fabrication of customizable small-caliber vascular grafts within minutes. FRJS facilitates independent control over nanofiber alignment and centimeter-scale vessel dimensions, yielding grafts with appropriate mechanical properties and flow characteristics. Four-week in vivo evaluation in a rat femoral vasculature replacement model demonstrated sustained vascular patency and early tissue remodeling, supporting the potential for intraoperative generation of tailored vascular conduits.

Advanced Materials
University of Zurich (CH), ETH Zurich (CH), Institute for Biomedical Engineering (CH), Swiss Institute for Regenerative Medicine (CH), University Hospital of Zurich (CH), Deutsches Herzzentrum der Charité (DE), Molecular Medicine Research Institute (US), Harvard Bioscience (United States) (US), Charité - Universitätsmedizin Berlin (DE)
Hartmann Müller-Stiftung für Medizinische Forschung, Jubiläumsstiftung von Swiss Life, UZH Foundation, NTT Research
Openalex Percentile: Top 18%
Electrospun Nanofibers in Biomedical Applications
DOISourceOpenAlex
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