The therapeutic potential of colchicine in oncology studies: from structural modification and targeted delivery to clinical management
druggability disconnect. Breakthrough paradigms like targeted protein degradation (TPD, e.g., PROTACs) and dynamic responsive carriers are subsequently proposed to guide the future precision clinical innovation of colchicine therapeutics.
Authors
- Siyuan Wu (ORCID: https://orcid.org/0000-0002-9041-8587)
- Yiran Ni (ORCID: https://orcid.org/0000-0001-6901-2980)
- Li Tian (ORCID: https://orcid.org/0000-0003-4484-5593)
- Junming Li (ORCID: https://orcid.org/0000-0003-1409-3634)
- Pengyu Jin
- Ziang Yuan
- Aidi Che
- Haiping Yao
Institutions
- China Three Gorges University (CN)
- Yichang Central People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-04-17
- DOI
- https://doi.org/10.3389/fphar.2026.1779469
- Primary Topic
- Protein Degradation and Inhibitors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Science and Technology Department of Hubei Province