Poly(allylamine)/tripolyphosphate nanocomplex coacervate as a NLRP3-dependent systemic and mucosal adjuvant for vaccines

, NP-OVA administration induced robust OVA-specific IgG and IgG2a responses, increased IFN-γ secretion by splenocytes, and elevated frequencies of CD4⁺IFN-γ⁺ and CD8⁺IFN-γ⁺ T cells. Comparable responses were observed following intranasal immunization, highlighting the versatility of these NPs as vaccine platforms. Overall, PAH/TPP NPs activate the NLRP3 inflammasome in innate immune cells, promote antigen-presenting cell maturation, enhance cytokine secretion, and induce strong Th1-biased humoral and cellular immune responses. These findings support their potential as a safe dual-function nanoplatform for preventive and therapeutic vaccines against infectious and non-infectious diseases.

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Publication Details

Journal
Frontiers in Immunology
Published
2026-04-17
DOI
https://doi.org/10.3389/fimmu.2026.1751634
Primary Topic
Immunotherapy and Immune Responses
Type
article
Field-Weighted Citation Impact
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article

Poly(allylamine)/tripolyphosphate nanocomplex coacervate as a NLRP3-dependent systemic and mucosal adjuvant for vaccines

Rodrigo C. Sanches, Eugenia Apuzzo, Waldemar A. Marmisollé, Maximiliano L. Agazzi et al.
Frontiers in Immunology
Immunotherapy and Immune Responses
article

Poly(allylamine)/tripolyphosphate nanocomplex coacervate as a NLRP3-dependent systemic and mucosal adjuvant for vaccines

Rodrigo C. Sanches, Eugenia Apuzzo, Waldemar A. Marmisollé, Maximiliano L. Agazzi, M. Lorena Cortez, Guillermo Docena, Santiago E. Herrera, Sérgio C. Oliveira, Omar Azzaroni, Camila Chavero, Daiana S. Bianchi, Analía S. Trevani, Gastón P. Rizzo, Irene A. Keitelman, Paola L. Smaldini
article en

Abstract

, NP-OVA administration induced robust OVA-specific IgG and IgG2a responses, increased IFN-γ secretion by splenocytes, and elevated frequencies of CD4⁺IFN-γ⁺ and CD8⁺IFN-γ⁺ T cells. Comparable responses were observed following intranasal immunization, highlighting the versatility of these NPs as vaccine platforms. Overall, PAH/TPP NPs activate the NLRP3 inflammasome in innate immune cells, promote antigen-presenting cell maturation, enhance cytokine secretion, and induce strong Th1-biased humoral and cellular immune responses. These findings support their potential as a safe dual-function nanoplatform for preventive and therapeutic vaccines against infectious and non-infectious diseases.

Frontiers in ImmunologyVol. 17
Universidade Federal de Minas Gerais (BR), Academia Nacional de Medicina (AR), Universidad Nacional de Río Cuarto (AR), Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (AR), Comisión de Investigaciones Científicas (AR), Instituto de Química y Fisicoquímica Biológicas (AR), Institute of Biomedical Science (GB), Fundación Ciencias Exactas y Naturales (AR)
Good health and well-being
Openalex Percentile: Top 23%
Immunotherapy and Immune Responses
DOIOpen Access PDFOpenAlex
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