Copper‐Catalyzed Three‐Component Reactions to Access Antitumor 5‐Methylseleno Triazoles
ABSTRACT A versatile copper‐catalyzed C‐H methylselenation/cyclization reaction of terminal alkynes with alkyl azides and PhSO 2 SeCH 3 has been developed for the synthesis of 5‐methylseleno triazoles. The antiproliferative activities of all resulting 5‐methylseleno triazoles were evaluated against HCT15 and HCT116 cell lines. Notably, compounds 4n and 5c exhibited up to 1000‐fold greater activity compared to 1,2,3‐triazoles, demonstrating that the introduction of the methylseleno functional group can significantly enhance antitumor activity.
Authors
- Xiaomin Yu
- Wenxi Zhang (ORCID: https://orcid.org/0000-0002-8863-4838)
- Benben Cai
- Ge Wu (ORCID: https://orcid.org/0000-0001-8432-5272)
- Ying Liu (ORCID: https://orcid.org/0000-0002-1312-0146)
- Weiqiang Lin
- Jie Hu
Institutions
- Chinese Academy of Sciences (CN)
- Wenzhou Medical University (CN)
- Fujian Institute of Research on the Structure of Matter (CN)
- Taizhou First People's Hospital (CN)
- Shanxi Academy of Medical Sciences (CN)
Publication Details
- Journal
- Applied Organometallic Chemistry
- Published
- 2026-04-17
- DOI
- https://doi.org/10.1002/aoc.70583
- Primary Topic
- Click Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- State Key Laboratory of Structural Chemistry