Angelic Acid Prevents RANKL-Induced Osteoclastogenesis Through Pathway-Biased Inhibition of MAPK–NFATc1 Signaling

. These findings identify AA as a novel inhibitor of the RANKL-MAPK-NFATc1 axis, providing a mechanistic foundation for its therapeutic development in osteoporosis and other osteolytic diseases.

Authors

Mojtaba Tabandeh (ORCID: https://orcid.org/0000-0002-2158-2631)
Vishwa Deepak (ORCID: https://orcid.org/0000-0003-0268-8411)
Lifang Zhang

Institutions

Wenzhou-Kean University (CN)
Kean University (US)

Publication Details

Journal: Current Issues in Molecular Biology
Published: 2026-04-17
DOI: https://doi.org/10.3390/cimb48040412
Primary Topic: Bone Metabolism and Diseases
Type: article
Field-Weighted Citation Impact: 0.00

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article

Angelic Acid Prevents RANKL-Induced Osteoclastogenesis Through Pathway-Biased Inhibition of MAPK–NFATc1 Signaling

Mojtaba Tabandeh, Vishwa Deepak, Lifang Zhang

Apr 17, 2026

Current Issues in Molecular Biology

Bone Metabolism and Diseases

article

Angelic Acid Prevents RANKL-Induced Osteoclastogenesis Through Pathway-Biased Inhibition of MAPK–NFATc1 Signaling

Mojtaba Tabandeh, Vishwa Deepak, Lifang Zhang

April 17, 2026article en

Abstract

. These findings identify AA as a novel inhibitor of the RANKL-MAPK-NFATc1 axis, providing a mechanistic foundation for its therapeutic development in osteoporosis and other osteolytic diseases.

Current Issues in Molecular BiologyVol. 48(4)

Wenzhou-Kean University (CN), Kean University (US)

Good health and well-being

Openalex Percentile: Top 20%

Bone Metabolism and Diseases

DOI Open Access PDF OpenAlex

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Angelic Acid Prevents RANKL-Induced Osteoclastogenesis Through Pathway-Biased Inhibition of MAPK–NFATc1 Signaling — Mojtaba Tabandeh, Vishwa Deepak, et al. · Current Issues in Molecular Biology (2026) | TGRS Research Map | TGRS