Interactions between rare variants in DNA repair genes and cardiometabolic risk explain more variability in cognitive function
) with neurocognitive and brain outcomes. Most associations were observed for WMH (43 variants across 27 genes) and SDMT (26 variants across 17 genes). Most associations (60.8% of variants) were identified only in interaction models with CMRI. Associations across 35 of the 36 previously identified genes were also observed (p < 0.05) for dementia. Interactions between rare genetic variants involved in DNA repair mechanisms and cardiometabolic risk may explain some of the observed cognitive variability.
Authors
- Nicolas Cherbuin (ORCID: https://orcid.org/0000-0001-6481-0748)
- Erin Walsh (ORCID: https://orcid.org/0000-0001-8941-0046)
- Shea J. Andrews (ORCID: https://orcid.org/0000-0002-1921-9470)
- Lene Juel Rasmussen (ORCID: https://orcid.org/0000-0001-6864-963X)
- Letícia Camargo Tavares (ORCID: https://orcid.org/0000-0001-7278-0999)
- Mark A. Fraser (ORCID: https://orcid.org/0000-0001-7795-7968)
- Anne Brüstle
- Richard A. Burns
- Yuan (William) Li (ORCID: https://orcid.org/0000-0001-8275-2916)
Institutions
- Australian National University (AU)
- University of Copenhagen (DK)
- University of California, San Francisco (US)
Publication Details
- Journal
- GeroScience
- Published
- 2026-04-17
- DOI
- https://doi.org/10.1007/s11357-026-02238-3
- Primary Topic
- Cognitive Functions and Memory
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Australian National University