Dose-response relations and the moderators between different types of exercise with cognitive functions in older people with mild cognitive impairment: A secondary analysis of a randomized clinical trial

= 0.003). Age, body mass index (BMI), and physical activity levels at baseline were significant moderators of the relationship between AE dose and cognitive responses. In contrast, age, sex, and BMI appeared to moderate the RE dose-response relationship, although these findings were less robust.ConclusionsPositive dose-response relations may exist among older adults with MCI, particularly between RE dose and processing speed. Some key factors, including age, sex, BMI, and the baseline physical activity level, may influence how individuals respond to exercise dose. Our findings provide preliminary insights for developing personalized exercise programs to optimize intervention efficiency and maximize cognitive benefits.Trial registration numberChiCTR2100045582.